nwharbert8-ui/eif2s1-translational-qc-hub: v1.0.0 - Publication release
Abstract
Initial release accompanying manuscript submission. Key findings: EIF2S1–PELO convergence: J=0.526, ρ=0.987, 559 shared genes RQC enrichment: 8.0-fold (p=1.0×10⁻³) Proteostasis enrichment: 9.2-fold (p=6.3×10⁻⁹) Translation initiation NOT enriched (2.7-fold, p=0.17) Cross-stage coordination: mean r=0.772 vs 0.468 random (d=1.36) Robust to agonal stress (ρ≥0.998 all models) Replicates across 5 brain regions (ρ=0.81–0.94) Dataset: GTEx v8 Brain–Frontal Cortex BA9 (n=209, 16,212 genes)
Fields of Study & Subjects
RNA and protein synthesis mechanisms
Genetics
Aging
and Longevity in Model Organisms
Endoplasmic Reticulum Stress and Disease
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 12 February 2026
- Language
- EN