nwharbert8-ui/rqc-two-module: v1.0.0 - Publication release

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Authors: nwharbert8-ui
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Abstract

Initial release accompanying manuscript submission. Key findings: LTN1–NEMF convergence: J=0.461, ρ=0.986, 512 shared genes (~9× above random baseline) PELO divergence: J=0.165 (PELO–LTN1), J=0.156 (PELO–NEMF) Two-module partition ratio: 2.79× (LTN1–NEMF / max PELO pair) PELO unique genes (528): protein catabolism (p=9.35×10⁻²²) + RNA metabolism (Reactome p=1.58×10⁻²⁰) NEMF unique genes (246): histone modifying activity (p=2.16×10⁻⁵), epigenetic regulators 5.4-fold (p=1.6×10⁻⁷) 166 three-way shared genes enriched for ubiquitin–proteasome function Robust to agonal stress: rank preservation ρ≥0.998, partition ratio 2.70–2.82× across all models Replicates across 5 brain regions (ρ=0.81–0.94) Dataset: GTEx v8 Brain–Frontal Cortex BA9 (n=209, 16,225 genes)

Fields of Study & Subjects

Bioinformatics and Genomic Networks Genomics and Chromatin Dynamics Single-cell and spatial transcriptomics

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
12 February 2026
Language
EN