SCIRT, a stem cell inhibitory transcript is regulated as a specific component of the TE differentiation signature.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of stage specific regulation of SCIRT, a stem cell inhibitory transcript, controlled as a specific component of the TE differentiation signature. SCIRT changes seemed to function in lineage commitment in embryonic stem cells of the human embryo.
Fields of Study & Subjects
Pluripotent Stem Cells Research
Developmental Biology and Gene Regulation
Reproductive Biology and Fertility
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 12 February 2026
- Language
- EN
- Document type
- Preprint