Nuclear transport of protein and RNA cargoes is altered during TE commitment.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of nuclear transport machinery as lineage commitment cooperating factors in embryonic stem cells of the human embryo. This included Kapna2, which functions in transport of protein cargoes with classical NLSs. The findings demonstrate specific changes in cellular transport during a discrete stage of embryonic development, during lineage commitment of stem cells to the trophectoderm.
Fields of Study & Subjects
Nuclear Structure and Function
Developmental Biology and Gene Regulation
Pluripotent Stem Cells Research
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 12 February 2026
- Language
- EN
- Document type
- Preprint