The Systems Reallocation Model of Hyperglycemia: Revisiting the Milieu Intérieur in Contemporary Metabolic Regulation

Zenodo (CERN European Organization for Nuclear Research) 2026 Preprint Open access

Read full text
Authors: Aditya Mishra
DOI: 10.5281/zenodo.18622165
Cited by: 0

Abstract

This work presents a systems-level reinterpretation of hyperglycemia grounded in Claude Bernard’s concept of the milieu intérieur. It integrates peripheral tissue receptivity, neuro-endocrine governance, and hemodynamic modulation within a unified framework termed the Systems Reallocation Model. The model emphasizes adaptive versus maladaptive transitions in metabolic regulation and proposes that elevated circulating glucose reflects coordinated systemic redistribution rather than isolated pancreatic insufficiency.

Fields of Study & Subjects

Diabetes Management and Research Pancreatic function and diabetes Diabetes Cardiovascular Risks and Lipoproteins

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
12 February 2026
Language
EN
Document type
Preprint