Formulation and Evaluation of Quercetin Loaded Silver Nanoparticles in Hydrogel Effective Treatment of Acne

Acne vulgaris is one of the most prevalent skin diseases which affect almost 80% of adolescents in the world during their lifetime. Development of specific association between antibiotic and bacteria during repeated treatment develops antibiotic resistance. Quercetin is flavonoid widely used as medicine in ancient time. Treatment of acne has been considered as a major research area in pharmaceutical and personal cosmetic care industries. The aim of the present work was to evaluate the, green synthesis of Quercetin silver nanoparticle and to develop herbal topical gel formulation to treat acne. Quercetin is selected based on its antibacterial activity. Silver Nano particle was synthesized using 1 mM aqueous silver nitrate solution from Quercetin and formation of silver nanoparticle was confirmed by UV spectroscopy. The synthesized silver nanoparticles were stable, spherical shape with average particle size of 94.34 nm and the polydispersity index was found to be 0.307. Synthesized silver nanoparticles was incorporated into gel base and evaluated for its physical properties such as pH, viscosity, spreadability and antibacterial activity against Propionibacterium acne. The results obtained in the developed formulation showed no lumps, had uniform color dispersion and were free from any fiber and particle. It was also observed to have good spread ability, pH was found to be 6.71±0.04 to 7.10±0.02 similar to pH of the skin. The antibacterial study of the optimized formulation showed inhibitory activity against Propionibacterium acne. Synthesized silver nanoparticle of Quercetin showed higher activity than the pure Quercetin and plain silver nanoparticles. Hence, silver nanoparticle of Quercetin in aqueous gel-base can be used as an appropriate formulation for treatment of acne vulgaris.