Blood brain barrier: Drug Delivery Methods across the blood brain barrier

The blood-brain barrier (BBB) has been a great obstacle for brain drug delivery. The BBB in healthy brain is a dispersal barrier essential for protecting normal brain function by impeding most compounds from transiting from the blood to the brain; only small molecules can cross the BBB. Under firm pathological conditions of diseases such as stroke, diabetes, seizures, multiple sclerosis, Parkinson’s disease and Alzheimer disease. There are three types of barrier present in central nervous system such as Blood Brain Barrier, Blood Cerebra-Spinal Fluid Barrier, and Blood– Arachnoid Barrier. Alzheimer disease, Parkinson’s disease, epilepsy, psychiatric disorders or neurodegenerative diseases, different types of drugs are available. But they have some lacuna for transportation of drug though these barriers and reaching drug to the target site. As an importance, several strategies are currently being sought after to enhance the delivery of drugs across the BBB.