How does ketamine's mechanism of action contribute to its effects on psychotic depression symptoms?
Abstract
Ketamine, through its action on NMDA receptors and subsequent neuroplastic changes, rapidly alleviates symptoms of depression with psychotic features. Its mechanism includes modulation of brain networks and gene expression, although further research is needed to fully understand its long-term effects and precise pathways.
Fields of Study & Subjects
Treatment of Major Depression
Electroconvulsive Therapy Studies
Transcranial Magnetic Stimulation Studies
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 13 February 2026
- Language
- EN