Nod2 and AIRE exert mutual homeostatic control.
Abstract
We used a systems biologic approach to understanding homeostasis in the immune system. We identified a common regulatory network governed by two immune receptors of disparate function, Nod2 and the autoimmune regulator AIRE. A central component of homeostatic control jointly regulated by NOD2 and AIRE was the aryl hydrocarbon receptor (Ahr).
Fields of Study & Subjects
T-cell and B-cell Immunology
Immune Response and Inflammation
Psoriasis: Treatment and Pathogenesis
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 14 February 2026
- Language
- EN
- Document type
- Preprint