HLA-E and HLA-G are modulated during transition from pluripotency to the TE, but HLA-L is not.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of a function for class I HLA-E and HLA-G receptors in lineage commitment. The data - conserved expression between hES cells and the in vitro differentiated TE - suggested HLA-L marked primitive tissues. We recently demonstrated evidence supporting a developmental function for MHC receptors MICA and MICB.
Fields of Study & Subjects
Pluripotent Stem Cells Research
Reproductive System and Pregnancy
Developmental Biology and Gene Regulation
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 15 February 2026
- Language
- EN
- Document type
- Preprint