DMRT1 epigenetic control through Dlx5.
Abstract
We identified DMRT1 interaction partners by ectopic expression of DMRT1 in a human primordial germ-like stem cell culture system coupled with measurement of total transcription by next generation RNA-sequencing. DMRT1 interacted with the imprinting axis involving Xist-Dlx-Olig activation-repression through Dlx5. A second key transcriptional partner of DMRT1 in epigenetic reprogramming was Zic5.
Fields of Study & Subjects
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Epigenetics and DNA Methylation
Genetic Syndromes and Imprinting
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 16 February 2026
- Language
- EN
- Document type
- Preprint