Herbal and Natural Compounds in Neuropharmacology: Biochemical innovations of Bio molecules used to manage Migraine

Migraine is a severe neurovascular condition that can significantly impair daily functioning, yet there are several targeted, well-tolerated, and effective treatment options available. The use of formulations derived from plant sources shows considerable potential in discovering new therapeutic targets for migraine management. Consequently, it is crucial to conduct safety and efficacy assessments. This review examines various phytomedicines that may aid in treating migraines, including feverfew, butterbur, menthol, ginger, ergotamine, caffeine, cannabis, curcumin, ginkgo biloba, serotonin, luteolin, glutamate, riboflavin, lavender and chamomile,focusing on their mechanisms of action and supporting evidence for treatment of migraine. This systematic review suggests that various herbal remedies, owing to their wide range of physiological effects, may serve as effective additions to migraine treatment. However, more rigorous, high-quality research is needed to evaluate their effectiveness and safety.