Phytoestrogenic And Therapeutic Potential of Clitoria Ternatea (Blue Pea) In Menopause: A Comprehensive Review

Menopause is a natural physiological transition marked by permanent loss of ovarian function and reduced estrogen levels, leading to vasomotor symptoms, psychological disturbances, urogenital atrophy, metabolic changes, and increased risk of osteoporosis and cardiovascular diseases. Although hormone replacement therapy (HRT) is effective, its long-term use is associated with adverse effects such as hormone-dependent cancers and cardiovascular complications.Growing interest has focused on plant-derived phytoestrogens as safer alternatives. Clitoria ternatea L. (Blue Pea), rich in flavonoids, anthocyanins, and phytosterols, has shown promising phytoestrogenic and therapeutic potential. Preclinical evidence suggests mild estrogen receptor-β interaction along with antioxidant, anti-inflammatory, neuroprotective, and bone-protective effects. Experimental studies indicate its ability to alleviate menopausal symptoms and improve lipid, bone, cognitive, and emotional health with minimal toxicity. However, evidence is largely limited to in-vitro and animal studies, and clinical validation is insufficient. This review summarizes the phytochemistry, phytoestrogenic mechanisms, therapeutic evidence, formulation strategies, and safety profile of C. ternatea, highlighting its potential role in menopausal health management.