Shc3 and Sh-binding chemistry in embryonic development.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of a set of Shc3 and Sh-binding molecules with functions in lineage commitment in embryonic stem cells of the human embryo. Genes engaged included Stac, Sh3bp5, Sh2bp3 and Stap2.
Fields of Study & Subjects
Developmental Biology and Gene Regulation
Pluripotent Stem Cells Research
Reproductive Biology and Fertility
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 17 February 2026
- Language
- EN
- Document type
- Preprint