Sox2, Sox9, Sox4, Sox21, Sox8 and Sox3 are lineage commitment program factors in embryonic stem cells.

Zenodo (CERN European Organization for Nuclear Research) 2026 Preprint Open access

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Authors: Shahan Mamoor
DOI: 10.5281/zenodo.18669063
Cited by: 0

Abstract

We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of Sox homeoboxes functioning as lineage commitment factors in embryonic stem cells of the human embryo. The Sox homeoboxes with developmental potential included Sox2, Sox9, Sox4, Sox21, Sox8 and Sox3.

Fields of Study & Subjects

Pluripotent Stem Cells Research Developmental Biology and Gene Regulation Epigenetics and DNA Methylation

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
17 February 2026
Language
EN
Document type
Preprint