Emerging Strategies in Glioblastoma Therapy: Natural Drugs and Nanoparticle-Based Approaches

Glioblastoma is the most aggressive primary brain tumor associated with poor prognosis andlimited treatment outcomes standard therapies, including surgery, radiotherapy and chemotherapyprovide only marginal survival benefits due to the tumor's invasiveness and resistance mechanism.Recent research has focused on natural bioactive compound. Such as polyphenols , alkaloids andflavonoids which exhibit antitumor anti-inflammatory and apoptosis inducing properties . Inparallel nanoparticles-based drug delivery system have shown promise in enhancing drugsolubility improving blood brain barrier penetration and enabling targeted delivery with reducedsystemic toxicity. Together, these approaches offer a potential synergic strategy for