MULTIVARIATE INSIGHTS INTO THE RELATIONSHIP BETWEEN CARDIAC, OXIDATIVE, AND INFLAMMATORY BIOMARKERS IN EXPERIMENTAL RATS

Cardiac biomarkers are considered one of the fundamental elements in the evaluation of cardiac function, while oxidative stress and inflammatory processes can also be regarded as important factors in the assessment of cardiovascular health. This study examined the relationships between cardiac biomarkers, oxidative stress, and inflammation, aiming to uncover the multidimensional interactions among these parameters. Cardiac parameters, inflammatory cytokines, and oxidative stress markers in heart tissue were analyzed in twenty-four male rats. Pearson and canonical correlation analyses were employed to assess the complex relationships between these datasets. Creatine kinase (CK) and creatine kinase– myocardial band (CK-MB) were positively correlated with malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β) and negatively correlated with glutathione (GSH), glutathione peroxidase (GSH-Px) and catalase (p