NIKETAS - Geometric Disease State Simulator

NIKETAS - Geometric Disease State Simulator models disease progression as movement through geometric basin states. Each disease is represented as 7 basins connected by transition probabilities derived from published clinical data, with one irreversible trap state representing the terminal endpoint. Therapeutic interventions are modeled as geometric operators (detune, transit, resonant, compress) that modify basin stability and transition topology. 29 diseases across 8 categories: Infectious (HIV, TB, Malaria, Hepatitis C), Neurodegenerative (Alzheimer's, MS, Parkinson's, ALS, Huntington's), Autoimmune (Celiac, Lupus, Crohn's, Rheumatoid Arthritis, Type 1 Diabetes), Genetic (DMD, Cystic Fibrosis, Sickle Cell), Cancer (Breast, Lung, Colorectal, Pancreatic, Leukemia), Cardiovascular (Heart Failure, Stroke), Metabolic (Type 2 Diabetes, NAFLD, CKD), Respiratory (COPD, Asthma). Features: Real-time basin simulation with 6 visualization lenses. Monte Carlo cohort analysis with bootstrap 95% confidence intervals. Sensitivity analysis with tornado diagrams. Cross-disease 29×29 similarity matrix. Operator algebra optimization. Time-to-trap survival curves. Drug mechanism mapping. Publication-ready SVG export. Validation benchmarks against published clinical data. BibTeX citation and formal methods section. Custom disease JSON import. Light/dark theme. Full keyboard navigation. ARIA accessible. Single self-contained HTML file. Zero external dependencies. Runs in any modern browser. No installation required. Built for researchers. Fork it, modify it, extend it.