Transcriptomic clock models and rodent gene expression meta-dataset

Transcriptomic clock models and rodent gene expression meta-dataset This Zenodo record contains processed expression data and transcriptomic clock models in .pkl format generated in the manuscript "Universal Transcriptomic Hallmarks of Mammalian Aging and Mortality". Scripts for preprocessing and model application are available in GitHub repository (https://github.com/Gladyshev-Lab/tAge). Raw RNA-seq data are available at GEO under accession numbers GSE292843, GSE292884, and GSE293503, and are linked under the SuperSeries GSE292885. These models are provided for research use as described in the repository license. Citation Tyshkovskiy et al. (2026) Universal Transcriptomic Hallmarks of Mammalian Ageing and Mortality. Nature. License These transcriptomic clock models and associated tAge R package are distributed under the MGB Open Access License 1.0. These materials may be used for non-commercial academic purposes, subject to the license terms. Commercial uses require a separate commercial license or agreement with Mass General Brigham.https://github.com/Gladyshev-Lab/tAge/blob/main/LICENSE For questions about commercial use, please contact MGB Innovation / Business Development & Licensing: innovation@partners.org licensing@partners.org Updates in the new version: Module-specific transcriptomic clock models (including rodent and multi-species multi-tissue clocks of chronological age and expected mortality) have been added to the record. The annotations for 2 samples in the processed rodent gene expression tables ("Mouse_NewITPdata_UMHET3_Liver_C2017_UT_RaAc9_Female.UT11008" and "Mouse_NewITPdata_UMHET3_Liver_C2017_UT_RaAc9_Female.UT11019") have been corrected.