FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF VALGANCICLOVIR HYDROCHLORIDE BY USING NATURAL AND SYNTHETIC POLYMERS

Abstract: The present study focuses on the formulation and evaluation of sustained release matrix tablets of Valganciclovir Hydrochloride (VH) using both natural and synthetic polymers to enhance therapeutic efficacy and patient compliance. Various formulations were prepared utilizing different concentrations of Hydroxypropyl Methylcellulose (HPMC), Xanthan Gum, and Karaya Gum as matrix-forming agents. The pre-compression parameters including bulk density, tapped density, Carr’s index, Hausner’s ratio, and angle of repose were evaluated and found within acceptable limits, indicating good flow properties. Post-compression studies, such as hardness, thickness, friability, weight variation, and drug content, were also within pharmacopeial standards, confirming the uniformity and mechanical integrity of the tablets. In-vitro drug release studies were carried out for 12 hours using USP dissolution apparatus. Among all formulations, batch VH4 demonstrated a sustained and controlled drug release profile, achieving 99.14% drug release at the end of 12 hours, thereby considered the optimized formulation. This study concludes that a combination of natural and synthetic polymers can effectively control the release of Valganciclovir Hydrochloride, providing a promising approach for sustained drug delivery. Keywords: Valganciclovir Hydrochloride, HPMC, Xanthan Gum and Karaya Gum