BRS/The Brain Resilience Study: Cognitive performance on a test of pattern separation is associated with cortical thickness in older adults

Miranda Chang; Kelly Shen; Kashish Mehta; Aina Elina Roenningen; Santiago Isaac Flores-Alonso; Alex I. Wiesman; Anthony McIntosh; Brianne A. Kent

doi:10.5281/zenodo.18780676

BRS/The Brain Resilience Study: Cognitive performance on a test of pattern separation is associated with cortical thickness in older adults

Zenodo (CERN European Organization for Nuclear Research) 2026 Open access

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Authors: Miranda Chang, Kelly Shen, Kashish Mehta, Aina Elina Roenningen, Santiago Isaac Flores-Alonso, Alex I. Wiesman, Anthony McIntosh, Brianne A. Kent

DOI: 10.5281/zenodo.18780676

Cited by: 0

Abstract

Poster created for Cognitive Neuroscience Society (CNS) 2026 Annual Meeting. The Alzheimer's Disease (AD) signature cortical thickness can indicate underlying neurodegenerative processes and predict dementia in cognitively normal individuals. Ineffective pattern separation is hypothesized to underlie episodic memory impairments in AD. This study aimed to investigate how performance on a test of pattern separation is associated with the AD cortical signature in cognitively normal older adults.

Fields of Study & Subjects

Dementia and Cognitive Impairment Research Memory and Neural Mechanisms Memory Processes and Influences

Publication details

Journal / source: Zenodo (CERN European Organization for Nuclear Research)
Publication date: 26 February 2026
Language: EN