2001-2026: A quarter of a century has passed since the presentation and the publication of core clinical multiscale modeling components in 2001 that were used for the founding of in silico medicine as a distinct discipline in 2002

[Click the blue text below to visit the corresponding webpage or to download the corresponding article.] A quarter of a century has passed since I had the great opportunity to present the core clinical mechanistic multiscale modeling components that were used for the founding of in silico medicine as a distinct discipline - through the concrete paradigm of in silico radiation oncology - in 2002. The presentation took place within the framework of the 43rd Annual Meeting of the American Society for Radiation Oncology (ASTRO) that was held in San Francisco, California, USA (Moscone Convention Center), from November 4 to 8, 2001. The abstract of the presentation was published in the top-tier, premier journal in the field of radiation oncology "International Journal of Radiation Oncology, Biology, Physics" (often referred to as IJROBP or the "Red Journal"). The full citation of the abstract is Stamatakos, G.S., D.D. Dionysiou, K.S. Nikita, N. Zamboglou, D. Baltas, G. Pissakas, N.K. Uzunoglu, "In vivo tumor growth and response to radiation therapy: a novel algorithmic description," International Journal of Radiation Oncology, Biology, Physics, Volume 51, Issue 3, Supplement 1, 2001, p. 240. The corresponding pdf file is accessible through the present Zenodo record. This model of 2001 has proved to be the first digital twin (virtual human twin) in medicine and oncology, before even the formal terms "digital twin" and "virtual human twin" were coined (see [5]). It is worth noting that in silico medicine, aspiring, inter alia, to transform medicine into an exact scientific and technological discipline, so as to better support medical doctors in the processes of patient individualized decision making and treatment planning, started its formal trajectory within the actual medical environment by addressing real clinical needs. Georgios S. Stamatakos Research Professor, ICCS, ECE, NTUA Father of In Silico Medicine Related open access articles: [1] Stamatakos, G. (2026). History of the emergence and formalization of in silico medicine. Zenodo. https://doi.org/10.5281/zenodo.18328392 [2] Stamatakos, G. (2026). In Silico Radiation Oncology by Stamatakos et al in Proceedings of the IEEE 2002 – The foundational paper of in silico medicine as a discipline – Open Access Accepted Manuscript. https://doi.org/10.5281/zenodo.18317235 [3] Stamatakos, G. (2025, August 26). In silico medicine and digital twins (virtual human twins) through the foundational paradigm of in silico oncology: Historical landmarks and current evolutionary status - A Lecture by G. Stamatakos, the Father of In Silico Medicine. Zenodo. https://doi.org/10.5281/zenodo.18327123 [4] The video of the Avicenna Alliance - Association for Predictive Medicine webinar lecture of G. Stamatakos (2025) is openly accessible at https://www.youtube.com/watch?v=ibPPCy-Z3yo&t=5s [5] Stamatakos, G. (2026, May 27). History of science: the birth of the digital twin (virtual human twin) in oncology and medicine and the development of the Oncosimulator. Zenodo. https://doi.org/10.5281/zenodo.20412798 [6] Stamatakos, G. (2026, May 27). New postgraduate subject on multiscale cancer modeling and in silico medicine (MSCM & ISM) [2014]. Zenodo https://doi.org/10.5281/zenodo.20414026 [7] Stamatakos, G. (2026). Prof Georgios Stamatakos gets interviewed by The Yuan on the globally acknowledged emergence of in silico medicine – a news article published on the archived website of the VPH Institute on 25 July 2022. Zenodo. https://doi.org/10.5281/zenodo.20548838 [8] Link to the graphics video titled “Episode 9: Beating childhood cancer with in silico medicine” (2025). The video focuses on the use of the digital twin (virtual human twin) “Oncosimulator” in pediatric oncology for the individualization and optimization of cancer treatment through the conduct of in silico experiments (experiments on the computer) i.e. through in silico oncology: https://www.youtube.com/watch?v=SCIpzxq8zW4 [9] Stamatakos, G. (2026). The Oncosimulator: The First Patient Specific Virtual Human Twin or Medical Digital Twin. Zenodo. https://doi.org/10.5281/zenodo.23573979