broadinstitute/bican-mccarroll-manuscript1: Initial release of BICAN manuscript code

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Authors: alecw, jamesnemesh, kshakir
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Abstract

Initial Release of BICAN Analysis Code This is the first public release of code supporting the McCarroll BICAN manuscript (2026). It captures the analytical state of the project at this milestone and serves as a stable reference point for the results presented in the manuscript. This release includes the primary analytical workflows implemented as dedicated R packages, providing support for: Differential expression analysis eQTL analysis Donor age prediction from gene expression data Together, these components constitute the core analytical pipelines underlying the manuscript. In addition, this release includes the bican.mccarroll.figures package, which reproduces the main and supplemental figures presented in the manuscript using the outputs generated by the analytical workflows described above. This release is versioned pre-1.0 and reflects an analysis snapshot associated with manuscript preparation. Interfaces and implementation details may evolve prior to final submission and the 1.0 release. Additional analytical components are under active development and will be incorporated in subsequent minor releases prior to the 1.0 manuscript submission release.

Fields of Study & Subjects

Gene expression and cancer classification Genetic Associations and Epidemiology Single-cell and spatial transcriptomics

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
26 February 2026
Language
EN