jwilliams10/RareVariantPRS: v1.0.0

RareVariantPRS (RICE) v1.0.0 — Code accompanying the manuscript “Integrating Common and Rare Variants Improves Polygenic Risk Prediction Across Diverse Populations”. This repository implements RICE (polygenic Risk predictions Integrating Common and rarE variants), a framework that: builds a common-variant PRS via ensemble learning across candidate PRS methods, and builds a rare-variant PRS using gene/region-level rare-variant association testing with functional annotations and penalized regression,then combines both components for final prediction. The archive includes scripts for simulations and for analyses performed in UK Biobank and All of Us. Data note: UK Biobank and All of Us individual-level data are controlled-access and are not included; reproduction of real-data analyses requires appropriate approvals and access via the respective platforms.License: See LICENSE in the repository.