Efficacy and Enamel Safety Evaluation of a PAP-Based Herbal Whitening Strip: An In Vitro Comparative Study

This study evaluated the efficacy and enamel safety of a peroxide-free, PAP-based herbal whitening strip containing papain, bromelain, and Glycyrrhiza glabra extract. Twenty removed human premolars were artificially stained and treated for 14 days. We employed spectrophotometric ΔE analysis to see how well the medicine worked and enamel microhardness and surface roughness assessments to see how safe it was. The PAP-herbal system produced clinically significant whitening (ΔE = 6.5 ± 0.8; p < 0.05), accompanied by a minor reduction in enamel hardness and a moderate increase in surface roughness. These results show that PAP-herbal systems are good and safer than peroxide-based whitening treatments