CENTRAL AND PERIPHERAL ANALGESIC EFFECTS OF TRACHYSPERMUM ROXBURGHIANUM SEED

Background: Trachyspermum roxburghianum (Radhuni), a culinary spice traditionally used in Bangladesh for pain management, lacks thorough experimental validation of its analgesic properties. Objective: This study investigated the central and peripheral analgesic activities of the methanolic extract of Trachyspermum roxburghianum seeds (METRS) in Swiss albino mice. Peripheral analgesic activity was evaluated using the acetic acid-induced writhing test, while central analgesic activity was assessed via the tail immersion method. Result: METRS exhibited significant, dose-dependent analgesic effects in both models. In the writhing test, doses of 50, 100, and 200 mg/kg body weight produced inhibitions of 33.69%, 50.00%, and 58.69%, respectively. In the tail immersion test, the 200 mg/kg dose significantly prolonged reaction time and increased percentage elongation, demonstrating central analgesic activity comparable to the standard drug diclofenac sodium. Conclusion: The findings indicate that METRS possesses notable analgesic properties, likely mediated through the inhibition of inflammatory mediators and modulation of nociceptive pathways, thereby providing scientific validation for the traditional use of this culinary spice in pain management.