EVALUATION OF THE EFFECTS OF AQUEOUS EXTRACT OF SOME COMMON TRADITIONAL SPICES (CTS) ON HYPERCHOLESTEROL-INDUCED OXIDATIVE STRESS IN WISTAR- ALBINO RATS.

Evaluation of the effects of aqueous extract of some common traditional spices (CTS) on hypercholesterol-induced oxidative stress in Wistar-albino rats was done using standard analytical methods, involving GC-MS, Randox Laboratory Biochemical kits and spectrophotometer. The acute toxicity studies were carried out. Thirty-five Wistar albino rats weighing 100-150 g were purchased and housed in seven plastic cages of five rats per group. The rats were fed with normal rat chow. The group fed with chow and normal saline constituted the group 1(normal control), group 2 was administered 300 mg/kg body weight CTS extract only, while group 3 (Negative control) was induced oxidative stress using 30mg/kg body weight cholesterol in coconut oil. Group 4 was the standard and treated with 3mg/kg body weight atorvastatin. Groups 5,6, and 7 were treated with 100, 200 and 400mg/kg body weight CTS after stress induction respectively. All the treatments lasted for 21 days. Phytochemical analysis of the CTS extract revealed 11 bioactive compounds. For the negative control,there was a significant (p