IN VITRO EVALUATION OF ANTI-DIABETIC ACTIVITY OF VEPPAMPOO (NEEM FLOWER)

Introduction: Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia and long-term complications. Plant-derived bioactive compounds are increasingly investigated as safer alternatives to conventional antidiabetic drugs. Azadirachta indica (Neem) is widely recognized in traditional medicine for its diverse pharmacological properties. Aim: The aim of the study is to evaluate the anti-diabetic activity of Veppampoo (Neem Flower) through invitro analysis. Methods: The present study assessed the in vitro antidiabetic activity of Veppampoo (Neem Flower) extracts using α-amylase and α-glucosidase inhibition assays, key enzymatic targets in carbohydrate digestion. Results: Veppampoo extracts demonstrated dose-dependent inhibitory activity against both enzymes, indicating their potential to reduce postprandial glucose levels by delaying carbohydrate hydrolysis and absorption. Conclusion: These findings suggest Veppampoo as a promising natural source of antidiabetic agents. Further studies involving bioactive compound isolation, mechanistic evaluation, and in vivo validation are required to establish clinical relevance.