DEVELOPMENT AND OPTIMIZATION OF A LIPID-BASED SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) FOR ENHANCING THE LYMPHATIC ABSORPTION AND BIOAVAILABILITY OF SILYMARIN.
Abstract
Background: Silymarin, a potent hepatoprotective agent, suffers from poor aqueous solubility (BCS Class II/IV) and extensive first-pass metabolism, leading to low oral bioavailability (
Fields of Study & Subjects
Drug Solubulity and Delivery Systems
Advanced Drug Delivery Systems
Proteins in Food Systems
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 1 March 2026
- Language
- EN