CORRELATION OF HEMOSTASIS AND ENDOTHELIAL DYSFUNCTION IN AUTOIMMUNE THYROIDITIS

Zenodo (CERN European Organization for Nuclear Research) 2026 Dataset Open access

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Authors: Babadjanova Shaira Agzamovna Bekchanova Nazokat Ikrom kizi, Worldy Knovledge Publishing Centre
DOI: 10.5281/zenodo.18825436
Cited by: 0

Abstract

Autoimmune thyroiditis (AIT) at the hypothyroid stage is characterized by hypocoagulable changes and endothelial dysfunction. This study aimed to assess the correlations between hemostatic parameters and endothelial markers in AIT. A total of 70 patients with AIT (subclinical and overt hypothyroidism) and 20 healthy controls were examined. Hemostatic indices included activated partial thromboplastin time (APTT), prothrombin index (PTI), fibrinogen concentration, and von Willebrand factor (vWF). Endothelial dysfunction was assessed by serum endothelin-1 (ET-1) and soluble intercellular adhesion molecule-1 (sICAM-1). Results demonstrated significant prolongation of APTT (26.0 → 46.1 s, p

Fields of Study & Subjects

Thyroid Disorders and Treatments Blood properties and coagulation Blood Coagulation and Thrombosis Mechanisms

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
1 March 2026
Language
EN
Document type
Dataset