Data and code from "Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition"

Zenodo (CERN European Organization for Nuclear Research) 2026 Dataset Open access

Read full text
Authors: Clayton W. Kosonocky, Alex Abel, Aaron L. Feller, Amanda Cifuentes Rieffer, Phillip R. Woolley, Jakub Lála, Daryl Barth, Tynan P. Gardner, Stephen Carl Ekker, Andrew D. Ellington, Wesley A. Wierson, Edward M. Marcotte
DOI: 10.5281/zenodo.18840100
Cited by: 0

Abstract

This contains the data generated in the Bits to Binders protein design competition; associated with the manuscript "Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition". This dataset contains experimental readouts from 12,000 AI-driven CD20-targeting protein binder designs that were validated in the context of CAR-T cells. This dataset also contains computational metrics computed from the sequences, and all code used in their analysis.

Fields of Study & Subjects

CAR-T cell therapy research Monoclonal and Polyclonal Antibodies Research Protein Degradation and Inhibitors

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
2 March 2026
Language
EN
Document type
Dataset