Effect of Natural Polymer and Excipients on Gastro Retentive Behavior of Floating Ranitidine Tablet

The current study was designed for the preparation of a gastro-retentive floating tablet of Ranitidine HCL by using combination of natural polymer Tara gum and synthetic polymer hydroxyl propyl methyl cellulose in an attempt to delay its gastric retention time and the side effects which occurs in marketed preparataion. The tablet was manufactured by the direct compression method. The outcome of varying concentrations of HPMC, Tara gum with sodium bicarbonate and citric acid for gas generating agent and magnesium stearate and talc. The preparation was augmented on the basis of adequate tablet qualities, total duration of floating, floating lag time, and in vitro drug release. The prepared tablet was found to have optimal hardness, low friability, consistent weight uniformity, and thickness. Dissolution study and floating lag time result indicated that formulation F6 showed better and controlled release of a drug. The floating lag time was 03min 30second and the total floating time was 6 hours. FTIR spectroscopy studies showed no interaction between the used polymer and the drug. The result indicated that a combination of synthetic and natural polymers reduces side effects and shows the best result[4,5].