Analysis code for: Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in vivo
Abstract
Analysis code supporting the manuscript 'Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in vivo'. Contains two components: (1) R statistical analysis of mtDNA heteroplasmy inheritance from neural stem cells to progeny, including mixed-effects models, Monte Carlo simulations, and Approximate Bayesian Computation (heteroplasmy_analysis/; Abhilesh Dhawanjewar); (2) Fiji/ImageJ macros for quantifying mtDNA nucleoid colocalization, TFAM association, and mitochondrial retention from single-molecule FISH imaging data (imaging_analysis/; Suvagata Roy Chowdhury)
Fields of Study & Subjects
Mitochondrial Function and Pathology
Autophagy in Disease and Therapy
Forensic and Genetic Research
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 3 March 2026
- Language
- EN