Analysis code for: Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in vivo

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Authors: Abhilesh S Dhawanjewar, Suvagata Roy Chowdhury
Cited by: 0

Abstract

Analysis code supporting the manuscript 'Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in vivo'. Contains two components: (1) R statistical analysis of mtDNA heteroplasmy inheritance from neural stem cells to progeny, including mixed-effects models, Monte Carlo simulations, and Approximate Bayesian Computation (heteroplasmy_analysis/; Abhilesh Dhawanjewar); (2) Fiji/ImageJ macros for quantifying mtDNA nucleoid colocalization, TFAM association, and mitochondrial retention from single-molecule FISH imaging data (imaging_analysis/; Suvagata Roy Chowdhury)

Fields of Study & Subjects

Mitochondrial Function and Pathology Autophagy in Disease and Therapy Forensic and Genetic Research

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
3 March 2026
Language
EN