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Abstract Objective: The aim of this study was to evaluate the left ventricular systolic function in hypertensive patients with left ventricular hypertrophy. Materials and methods: We studied 112 cases with aged 40-69 years and were divided into two groups: the first group included 74 hypertensive patients, in there 38 hypertensive patients without left ventricular hypertrophy and 36 hypertensive patients with left ventricular hypertrophy; the second group included 38 cases without hypertension and cardiovascular disease (normal control subjects). Methods: Prospective, descriptive and compared to normal control subjects. Results: There was no signigficant difference (p > 0.05) between hypertensive group and focus group at age, gender, BMI, BSA and Glycemia. In hypertensive patients group with left ventricular hypertrophy, left ventricular ejection fraction (EF: 66.43 ± 6.10%) and left ventricular shortening fraction (FS: 36.66 ± 3.72%) were lower than normal control subjects (EF: 69.16 ± 6.42% and FS: 38.33 ± 3.96%) with significantly difference (p < 0.05) and there was no signigficant difference (p > 0.05) with hypertensive patients group without left ventricular hypertrophy (EF: 68.16 ± 6.42% và FS: 37.12 ± 3.96%) Conclusion: In hypertensive patients with left ventricular hypertrophy, left ventricular ejection fraction (EF) and left ventricular shortening fraction (FS) have impaired compared to normals (p < 0.05). Key words: Hypertension, left ventricular systolic function, echocardiography.