Is hepatotoxicity a potential adverse effect of Sulfamethoxazole/Trimethoprim (SMX/TMP)?

They are a commonly used antimicrobial agent for the treatment of bacterial infections of the urinary tract, otitis media, bronchitis, traveler’s diarrhea, shigellosis, Pneumocystis jirovecii pneumonia (PJP), and community-acquired infections caused by methicillin-resistant Staphylococcus aureus (MRSA).This combination is particularly indicated for the management of bacterial infections in patients with HIV, such as pneumocystis pneumonia (prophylaxis and treatment), isosporiasis, salmonellosis, toxoplasma encephalitis (prophylaxis and treatment). It is also indicated in the management of exacerbations of chronic obstructive pulmonary disease (COPD), pulmonary cystic fibrosis, infections with Aeromonas, infections resulting from animal bites, bacterial endocarditis, bacterial keratitis, meningitis, cholera, cyclosporiasis, diabetic foot infection, diverticulitis, infectious arthritis, osteomyelitis, pertussis, prostatitis, sepsis, and sinusitis.