Comparison of Efficacy and Safety Between Sugammadex and Neostigmine in Reversal of Vecuronium Induced Neuromuscular Blockade in Adults

Introduction: A Reversal agents restore neuromuscular function after muscle relaxants; neostigmine has side effects, while sugammadex specifically reverses aminosteroidal neuromuscular blockers. Aim: To compare the recovery time, haemodynamic stability and complications between neostigmine of 70 mcg/kg + glyco 10mcg/kg & sugammadex - 4 mg /kg in antagonizing the effects of vecuronium in adults. Methodology : This prospective randomized,double - blinded controlled trail included 60 adult patients (18-70 years )undergoing surgery under general anaesthesia requiring vecuronium. Patients were randomly allocated into 2 groups: Group N: neostigmine (70mcg/kg with glycopyrrolate 10mcg/kg)& Group S: sugammadex (4mg/kg). Neuromuscular monitoring was performed using acceleromyography with train -of-four(TOF)stimulation. Recovery time from reversal administration at TOF count 4, haemodynamic parameters, post extubation complications were recorded. Results : The mean recovery time was significantly longer in the neostigmine group (11.26±3.53 mins) compared to the sugammadex group(5.6±1.56 mins) with a mean difference of 5.66 mins with significant p value(p