How does trimethoprim cause gastrointestinal side effects?

Zenodo (CERN European Organization for Nuclear Research) 2026 Open access

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Authors: Tripdatabase
DOI: 10.5281/zenodo.18876894
Cited by: 0

Abstract

Trimethoprim often causes gastrointestinal side effects such as nausea and diarrhea, likely due to changes in gut flora, especially when used with sulfamethoxazole. Evidence primarily comes from combinations with sulfamethoxazole rather than trimethoprim alone.

Fields of Study & Subjects

Gut microbiota and health Pharmacovigilance and Adverse Drug Reactions Gastrointestinal motility and disorders

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
5 March 2026
Language
EN