ROLE OF CHOLINERGIC NEUROTRANSMISSION IN COGNITIVE DECLINE ASSOCIATED WITH CHRONIC OBSTRUCTIVE AND CARDIOVASCULAR DISORDERS
Abstract
Introduction.Cognitive impairment is a common comorbidity in patients with chronic obstructive syndrome (COS) in the presence of cardiovascular pathology (CVD). The main mechanisms include chronic hypoxemia, systemic inflammation, endothelial dysfunction, and imbalance of the autonomic nervous system [1–3,5]. Recent studies indicate that cholinergic dysfunction is a key integrative mechanism linking peripheral pathology with cognitive decline [7,8].
Fields of Study & Subjects
Neurological Disease Mechanisms and Treatments
Dementia and Cognitive Impairment Research
Chronic Obstructive Pulmonary Disease (COPD) Research
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 5 March 2026
- Language
- EN
- Document type
- Dataset