A serpin-myeloid axis in pancreatic cancer heterogeneity and immune evasion
Abstract
PDAC forms a dense, T-cell-excluded tumor microenvironment, but the molecular drivers of this niche remain unclear. Using Perturb-map, a spatial functional genomics platform, we identify the fibrinolysis regulators Serpinb2 (PAI-2) and Serpine1 (PAI-1) as key mediators of immune evasion. Tumor-derived SERPINs stabilize a fibrin-rich ECM that anchors macrophages, promotes immunosuppressive polarization, and excludes cytotoxic T cells. Their deletion suppresses tumor growth and sensitizes PDAC to anti-PD-1 therapy.
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 24 July 2026
- Language
- EN
- Document type
- Dataset