Neuroinflammatory Architecture and Neural Vulnerability: Microglial Regulation, Synaptic Integrity, and Threshold Dynamics in Neurodegeneration

This master monograph presents a systems-level framework of neuroinflammatory architecture as a central determinant of neural vulnerability. Integrating microglial regulation, complement-mediated synaptic remodeling, metabolic constraints, and vascular integrity, it reconceptualizes neurodegeneration as a threshold phenomenon emerging from sustained perturbations in neural homeostasis. All references (1–80) are fully integrated, supporting rigorous scholarly citation. This version corresponds to the master monograph submitted to Frontiers in Neuroscience, Section Neurodegeneration (Manuscript ID: 1823810, submitted 05 March 2026). The work is archived for permanent open-access citation via Zenodo, ensuring international visibility and traceable scholarly impact. Figures, tables, and supplementary materials are included where relevant.