Formulation And Process Validation of Clindamycin Hcl Emulgel

Aims: The aim of the present study was to develop an emulgel formulation of Clindamycin Hydrochloride using carbopol 934 as a gelling agent. The influence of the type of gelling agent and the concentration of both the oil phase and the emulsifying agent on the release of the drug were investigatedMethodology: Within the major group of semisolid preparations, emulgel has emergedas a promising drug delivery system for the delivery of hydrophobic drugs. Different emulgel formulations were prepared using gelling agent carbopol 934, liquid paraffin (6% and 8 %) and emulsifying agent (Span 2 and 2.5% and tween 1 and 1.5 %). The prepared emulgel were evaluated for their physical properties, pH, drug content, rheological properties and in vitro release studies. Results: All the prepared emulgels showed acceptable physical properties concerning colour, homogeneity, consistency, and pH value. revealed that all formulations exhibited a shear thinning behaviour with thixotropy, indicating structural break down of intermolecular interaction between polymeric chains. The prepared emulgel exhibited higher release in F6 formulation. Stability studies revealed no significant differences before and after storage of formulation for a period of 3 months.Conclusion: It was suggested that Clindamycin Hydrochloride emulgel formulation (F6) prepared using carbopol as gelling agent, emulsifying agent in its high level and liquid paraffin in its high level was the formula of choice since it showed the highest drug release