Assessment of Liver Damage in Patient with Alcoholic Liver Disease at District General Hospital, Amravati

Background: Alcoholic Liver Disease (ALD) remains a major cause of chronic liver morbidity and mortality worldwide, particularly in developing regions where alcohol misuse is prevalent. Early detection and assessment of disease severity are essential to prevent progression to advanced fibrosis and cirrhosis. Objective: To assess the extent of liver damage in patients diagnosed with Alcoholic Liver Disease at District General Hospital, Amravati, using demographic, clinical, laboratory, radiological, and non-invasive fibrosis markers. Methods: A hospital-based prospective observational study was conducted among 210 patients with confirmed ALD. Patients were categorized into alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis. Demographic data, alcohol consumption patterns, hematological parameters, liver function tests, ultrasonographic findings, and non-invasive fibrosis indices (De Ritis ratio, APRI, and FIB-4) were analyzed. Results: The study population showed a strong male predominance (97%), with most patients belonging to the 31–50 years age group. Daily alcohol intake was the predominant pattern, and higher consumption (≥180 ml/day) over prolonged duration (5–20 years) was strongly associated with advanced disease. Laboratory findings revealed anemia, thrombocytopenia, elevated AST and ALT levels, hyperbilirubinemia, and hypoalbuminemia. Non-invasive fibrosis markers indicated significant fibrosis in a substantial proportion of patients, particularly in the cirrhosis subgroup. Ultrasonography commonly demonstrated hepatomegaly, fatty infiltration, ascites, and splenomegaly. Conclusion: Chronic heavy alcohol consumption, especially in rural and socioeconomically vulnerable populations, is strongly associated with progressive liver damage. Integrated assessment using clinical evaluation, laboratory parameters, imaging, and non-invasive fibrosis scores is essential for early detection and severity stratification of Alcoholic Liver Disease.