Unbiased discovery of genes required for pluripotency: UNC13A.
Abstract
Qualities of the stem cells of the embryo or the gametes include pluripotency and totipotency. Pluripotency as a quality that defines the embryonic stem cell is likely a process or entity distinguishable from the multi-lineage differentiation capacity that defines the HSC. We separated hematopoietic stem and embryonic stem programs for blind discovery of pluripotency-associated factors in the ES cell. We describe identification of UNC13A as a factor regulating or associated with pluripotency in human embryonic stem cells.
Fields of Study & Subjects
Pluripotent Stem Cells Research
Developmental Biology and Gene Regulation
Mesenchymal stem cell research
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 8 March 2026
- Language
- EN
- Document type
- Preprint