Hnf1b functions in embryonic stem cell fate choice during endoderm lineage specification.
Abstract
The organ systems of the human body are each derived from three germ layers: the endoderm, mesoderm, and ectoderm. We defined here using transcriptomics a minimal set of components required or important for germ layer fate choice to the endoderm in the first trimester of human development. We describe a requirement for Hnf1b in germ layer lineage choice from pluripotent stem cells in Homo sapiens.
Fields of Study & Subjects
Pluripotent Stem Cells Research
Developmental Biology and Gene Regulation
Neurogenesis and neuroplasticity mechanisms
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 8 March 2026
- Language
- EN
- Document type
- Preprint