Synergism in Solubility of Polyherbal Formulations of Garlic: Standardization and Optimization

Systems like Ayurveda, Traditional Chinese Medicine, Unani, Siddha rely on natural products as their foundation. Standardization of herbal plants should focus on reducing any potential toxicity and upholding the therapeutic efficacy, quality, and safety. Standardization involves the identification, authentication and quantification of active pharmacological constituents along with the evaluation of physicochemical parameters, to ensure quality assurance and maintain batch- to- batch consistency. The current study aims at the systematic standardization and optimization of garlic and O. sanctum to formulate a stable, pharmacodynamically active polyherbal preparation. Analytical evaluation methods were employed to assess the individual and synergistic contributions of these botanicals. It was observed that the solubility of active components derived from garlic exhibit greater when combined with tulsi due to synergistic effect. These findings provide a scientific foundation for the therapeutic importance of traditional herbal mixtures, emphasising the significance of physicochemical characterization for rational optimization of polyherbal formulations.