A Review: Neuroprotective Potential of Merremia Dissecta Leaves Against Scopolamine-Induced Memory Impairment

Neurodegenerative disorders such as Alzheimer’s disease are characterized by slowly memory loss and cognitive impairment , and the currently available pharmacological treatments provide only limited symptomatic benefits. Merremia dissecta is a medicinal plant traditionally used for various therapeutic purposes and has been reported to possess antioxidant, anti-inflammatory, and neuroprotective effects . Scopolamine-induced cognitive dysfunction is a wellestablished experimental model that mimics cholinergic deficits identified in Alzheimer’s disease. This review summarizes existing literature on the phytochemical constituents of Merremia dissecta leaves, including flavonoids, phenolic compounds, alkaloids, and glycosides, and discusses their possible mechanisms of action such as antioxidant activity, inhibition of acetylcholinesterase, and modulation of neuroinflammatory pathways. Overall, the reviewed evidence suggests that Merremia dissecta leaves may offer promising neuroprotective effects against scopolamine-induced memory impairment, warranting further experimental and clinical investigations