The HSC transcriptome is enriched for the expression of IBD risk factors.

Zenodo (CERN European Organization for Nuclear Research) 2026 Preprint Open access

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Authors: Shahan Mamoor
DOI: 10.5281/zenodo.18957408
Cited by: 0

Abstract

We measured total transcription in the HSC to determine without bias, with reference to the keratinocyte and the fibroblast, HSC signature genes. The analysis revealed a preponderance of IBD (inflammatory bowel disease)-associated genes. These genes included WAS, TAGAP, as well as a group of Sh3-domain factors. The total number of IBD risk factors genes enriched within the HSC transcriptome and relative position of the genes within the HSC transcriptome suggested specific importance of an HSC function in IBD.

Fields of Study & Subjects

Inflammatory Bowel Disease Skin and Cellular Biology Research Psoriasis: Treatment and Pathogenesis

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
11 March 2026
Language
EN
Document type
Preprint