Advances in Nanotechnology-Based Delivery of Resveratrol: Challenges, Opportunities, and Therapeutic Applications with Mechanistic Insights.

Resveratrol, a naturally occurring polyphenolic molecule found in grapes, berries, and peanuts, holds tremendous medicinal potential because of its antioxidant, anti-inflammatory, neuroprotective, and cardioprotective effects. However, its therapeutic usage is hampered by poor water solubility, fast metabolism, and low oral bioavailability. distribution techniques based on nanotechnology have shown promise in overcoming these obstacles and improving resveratrol's stability, absorption, and targeted distribution. This study summarises current breakthroughs in nanocarrier platforms, including solid lipid nanoparticles, nanostructured lipid carriers, polymeric nanoparticles, liposomes, nanoemulsions, dendrimers, and nano-in-microparticle systems designed for resveratrol encapsulation. Key formulation characteristics including as particle size, zeta potential, encapsulation efficiency, and release behaviour are highlighted to demonstrate how nanoscale engineering improves pharmacokinetic and pharmacodynamic profiles.Studies reveal greater antioxidant capability, improved cellular absorption, prolonged release, and superior therapeutic effects against cardiovascular illnesses, diabetes, neurological disorders such as Alzheimer’s disease, and many malignancies when resveratrol is administered using nanocarriers. In conclusion, nanotechnology plays a critical role in overcoming the innate limits of resveratrol, considerably enhancing its therapeutic efficacy. Continued research on optimised nanocarrier design, scalability, biocompatibility, and clinical translation is required for establishing resveratrol-loaded nanosystems as effective and safe treatment modalities.