Five Axioms of the Universal Resonance Model Core Principles for Dynamic Disease Systems

This paper introduces the Five Axioms of the Universal Resonance Model (URM), a conceptual framework proposing that disease should be understood as a dynamical transition in complex biological systems rather than as a static pathological state. The model integrates principles from complex systems science, including relational signaling, system instability, and early warning signals such as rising variance and increasing autocorrelation. The framework also introduces the concept of a reset window, a temporal interval during which targeted interventions may restore system stability before a pathological regime becomes consolidated. The five axioms provide a foundational structure for studying disease dynamics across physiological systems and for developing future approaches to dynamic monitoring, predictive medicine, and systems-based clinical decision making.