HMCES and DNMT silencing in early embryonic development in humans.

Zenodo (CERN European Organization for Nuclear Research) 2026 Preprint Open access

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Authors: Shahan Mamoor
DOI: 10.5281/zenodo.18980892
Cited by: 0

Abstract

DNMT3A and DNMT3B expression are silenced together with HMCES and this occurs concomitant with GADD45A/B induction in early embryonic development in humans. HMCES silencing concomitant with DNMT3A and DNMT3B silencing between the 1st and 3rd cell divisions (1-cell to 8-cell embryo) occurred in a developmentally programmed fashion together with an expression switch involving switching from Tet3 to Tet1/2 expression.

Fields of Study & Subjects

Epigenetics and DNA Methylation Developmental Biology and Gene Regulation Genomics and Chromatin Dynamics

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
12 March 2026
Language
EN
Document type
Preprint